A novel outbreak enterovirus D 68 strain associated with acute flaccid myelitis 1 ! cases in the United States from 2012 - 2014 : a retrospective cohort study
نویسندگان
چکیده
Alexander L. Greninger, M.D., Ph.D., Samia N. Naccache, Ph.D., Kevin 4! Messacar, M.D., Anna Clayton, B.S., M.P.H., Guixia Yu, B.S., Sneha Somasekar, 5! B.S., Scot Federman, B.A., Doug Stryke, B.S., Christopher Anderson, B.S, 6! Shigeo Yagi, Ph.D., Sharon Messenger, Ph.D. , Debra Wadford, Ph.D. , Dongxiang 7! Xia, M.D., Ph.D., James P. Watt, M.D., M.P.H. , Keith Van Haren, M.D., Samuel R. 8! Dominguez, M.D., Ph.D., Carol Glaser, D.V.M., M.D., Grace Aldrovandi, M.D., and 9! Charles Y. Chiu, M.D., Ph.D.* 10! 11! Affiliations: 12! University of California, San Francisco, CA, USA 13! UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, USA 14! Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, 15! CO, USA 16! California Department of Public Health, Richmond, CA, USA 17! Lucile Packard Children's Hospital at Stanford University, Palo Alto, CA, USA 18! Children's Hospital Los Angeles and University of Southern California, Los Angeles, 19! CA, USA 20! 21! These authors contributed equally to the manuscript. 22! *corresponding author 23! Charles Chiu 24! Department of Laboratory Medicine 25! University of California, San Francisco, San Francisco, CA 26! [email protected] 27! 28!
منابع مشابه
A novel outbreak enterovirus D68 strain associated with acute flaccid myelitis cases in the USA (2012-14): a retrospective cohort study.
BACKGROUND Enterovirus D68 was implicated in a widespread outbreak of severe respiratory illness across the USA in 2014 and has also been reported sporadically in patients with acute flaccid myelitis. We aimed to investigate the association between enterovirus D68 infection and acute flaccid myelitis during the 2014 enterovirus D68 respiratory outbreak in the USA. METHODS Patients with acute ...
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INTRODUCTION The association between enterovirus D68 and acute flaccid myelitis was first described in the United States in 2014. Since then, sporadic cases have been reported in Canada and Europe. This study describes a series of cases of acute flaccid myelitis at Hospital de Pediatría "Prof. Dr. Juan P. Garrahan," in Buenos Aires, Argentina, during 2016. METHODS Descriptive, retrospective s...
متن کاملRe-analysis of metagenomic sequences from acute flaccid myelitis patients reveals alternatives to enterovirus D68
Metagenomic sequence data can be used to detect the presence of infectious viruses and bacteria, but normal microbial flora make this process challenging. We re-analyzed metagenomic RNA sequence data collected during a recent outbreak of acute flaccid myelitis (AFM), caused in some cases by infection with enterovirus D68. We found that among the patients whose symptoms were previously attribute...
متن کاملRe-analysis of metagenomic sequences from acute flaccid myelitis patients reveals alternatives to enterovirus D68
Metagenomic sequence data can be used to detect the presence of infectious viruses and bacteria, but normal microbial flora make this process challenging. We re-analyzed metagenomic RNA sequence data collected during a recent outbreak of acute flaccid myelitis (AFM), caused in some cases by infection with enterovirus D68. We found that among the patients whose symptoms were previously attribute...
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Enterovirus D68 (EV-D68), phylogenetic clade B was identified in nasopharyngeal specimens of two cases of severe acute flaccid myelitis. The cases were six and five years-old and occurred in September and November 2014. EV-D68 is increasingly associated with acute flaccid myelitis in children, most cases being reported in the United States. Awareness of this possible neurological complication o...
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